Wet mixing pellet machine is the core equipment for preparing granules in industries such as pharmaceuticals, food, and chemicals. Its operating standards directly affect the quality of granules, production efficiency, and equipment life. The following is an analysis of the key points of the entire process operation to help achieve safe, efficient, and compliant production.
1、 Pre boot check: Details determine success or failure
1. Confirmation of the status of the wet mixing pellet machine
① Check that the mixing blade and cutting blade are not worn or loose, the lubrication system oil level is normal, and the pneumatic valve is flexible and not stuck.
② Conduct a 3-minute no-load test run to detect any abnormal noise from the mechanical transmission components and ensure smooth operation of the equipment.
2. Material preparation requirements
① The moisture content of the powder is 5%, and it needs to be sieved through a 60 mesh sieve to remove clumps; Adhesives (such as starch slurry) should be preheated to 60-70 ℃ to ensure uniform dispersion.
② Weigh the raw materials according to the prescription amount, and control the error within the range of± Within 0.5%, different materials must be strictly input in order.
2、 Accurate control of operating parameters
1. Wet mixing stage
① After starting the wet mixing pellet machine, mix the dry powder at low speed (50-80 rpm) for 5 minutes, and then gradually increase the speed to 120-150 rpm to add the binder.
② The mixing time is based on the uniform and moist state of the material, usually lasting 10-15 minutes. Excessive addition of liquid can easily cause the particles to become too soft.
2. Granulation cutting parameters
① Set the cutting blade speed to 200-250 rpm, creating a reverse shear force with the stirring blade to promote particle formation.
② The particle size can be adjusted by the height of the cutting head, with a common range of 500-1000 μ m. It is necessary to observe the uniformity of the discharged particles in real time to avoid differences in thickness>; 20%.
3、 Shutdown maintenance and compliance records
1. Batch cleaning and key point inspection
① Stop feeding first, continue running idle for 2 minutes to empty the residual slurry, and then clean the chamber and cutting tools with purified water.
② The key inspection is to check whether the screen mesh is damaged. If the aperture deviation is greater than 80 μ m, it needs to be replaced immediately. Equipment that meets GMP requirements needs to be printed and archived for parameters.
2. Quality verification and preventive maintenance
① The batch particle forming rate is 95%, the brittleness is less than 0.8%, and the moisture content is stable in the range of 2% -4%.
② Daily recording of the operating parameters of the wet mixing pellet machine, monthly detection of impeller radial runout<0.1mm, and annual calibration of pressure sensor accuracy by a third-party.
Operation motto: Wet granulation is a combination of art and science, which requires strict adherence to SOP and flexible adjustment of parameters based on material characteristics. It is recommended that enterprises establish equipment performance databases, optimize process parameters through historical data, and continuously improve production quality and efficiency.
