As a special dosage form, microspheres have significant advantages in drug sustained and controlled release, improving bioavailability, and other aspects. The main equipment in the microsphere production line is the key to achieving high-quality microsphere production.
1、 Extruder: the starting station for pellet molding
The extruder is the starting equipment of the pellet production line, and its main function is to extrude materials into uniform strips. It applies pressure to the material through a rotating screw, causing it to be extruded through a specific mold at a certain temperature and shear force. High quality extruders can precisely control the extrusion speed, temperature, and material density, ensuring that the extruded strip-shaped material is uniform and smooth on the surface, providing a good foundation for subsequent pelletizing processes.
2、 Rolling machine: endowing pellets with shape
The rolling machine plays the role of rolling strip-shaped objects into spherical shapes in pellet production. It utilizes a high-speed rotating turntable and a special design of the inner wall to gradually roll the strip into a spherical shape under the action of centrifugal force. The rotational speed of this device, the tilt angle of the turntable, and the precision of the internal structure all affect the roundness of the pellets. High precision rolling machines can produce pellets with regular shapes and uniform sizes, greatly improving product quality and appearance consistency.
3、 Drying machine: a key link in stabilizing the quality of microspheres
The function of a dryer is to remove excess moisture from the microspheres during the molding process. For microspheres, appropriate drying conditions are crucial. Excessive temperature may cause surface cracking or internal structural changes in microspheres, while excessively low temperature can prolong drying time and affect production efficiency. The advanced dryer adopts low-temperature drying technology, combined with precise temperature and humidity control system, which can improve drying efficiency while ensuring the stability of pellet quality, and ensure that the moisture content of pellets meets the standard requirements.
4、 Coating machine: endowing microspheres with special functions
The coating machine is used for coating micro pills, which can not only improve the appearance of micro pills, but also achieve various functions such as slow and controlled release. The coating material is evenly sprayed on the surface of the pellets by means of spray, and then dried and solidified. Accurate liquid supply system and stable air intake system are the key to the normal operation of the coating machine, which can ensure the uniform thickness of the coating layer, thereby ensuring that the drug release characteristics of the microspheres meet expectations.
The main equipment in the pellet production line cooperate with each other, and each device plays a crucial role in building an efficient and accurate pharmaceutical core system, from the initial formation of pellets to the final exquisite packaging.
